The purpose of this study was to determine the some toxicokinetic parameters of cyanide and thiocyanate in mice experimentally poisoned with sodium cyanide. In the study, 200 mice, 40-50 g weights, were used. Sodium cyanide were given intraperitoneally in doses of 0,1, 0.2, 0.4 and 0.8 mg/kg. Then, some toxicokinetic parameters of the cyanide and thiocyanate like as distribution half-life, elimination half-life, mean existence lime and area under the curve (AUC) in the blood samples drawn at 6, 12, 30, 60, 120, 240, 360 ve 720th minutes were determined. The distribution half-lifes ol blood cyanide levels were, respectively, 0.04±0.02, 0.05±0.009. 0.06±0.008 and 0.08±0.01th hour; the elimination half-lifes were, respectively, 3.06±0.14, 2.36±0.02, 2.33±0.03 and 2.28±0.06 hours; the duration of maximal concentration was 12 minutes and the maximal blood levels, according to doses, respectively, were 0.153, 0.308, 0.350 and 0.376 µ,g/ml. Besides. mean existence times were, respectively, 4.53±0.20, 3.50±0.03, 3.46±0.05 and 3.43±0.12 hours and AUC values according to doses were, respectively, 33.50±2.62, 45.40±1.84, 48.91±2.77 and 58.47±2.54 µg.hour/ml were observed. The distribution half-lifes of blood thiocyanate levels were, respectively, 0.07±0.008, 0.09±0.005, 0.09±0.005 and 0.18±0.05 hours; the elimination hall-lifes were, respectively, 62.80±19.36, 25.79±2.65, 14.48±0.41 and 14.53±0.80 hours; the duration of maximal concentration 120 minutes and the maximal blood levels according to doses were, respectively, 0.265, 0246, 0.408 and 0.444 µg/ml. Besides, mean existence times were, respectively, 90.27±27.95, 37.37±3.83, 21.04±0.59 and 21.27±1.17 hours and AUC values according to doses were, respectively, 79.13±54.19, 28.06±15.38, 8.92±0.45 and 89.22±49.91 µg.hour/ml.