After inspection and radiological examinations, meningocele was suspected on a 2-day old Brown swiss male calf which was brought dead to the Department of Pathology, Faculty of Veterinary Medicine in Dicle University. As a result of the anatomopathologic analysis, a saclike protrusion that was 17x15 cm sized fluctuant and covered with a hairy skin was observed on frontal squama. In the pouch, approximately 200 mL serous fluid mixed with blood were seen. The brain was also protrused with meninges rostro-dorsal to frontal region. Ethmoid bone was formed rudimentary, so ethmoid labyrinths was not detected in this region. On the other hand, absences of nasal bone, nasal part of frontal bone, nasal conchae and rostral half of hard palate were detected. Cerebral hypoplasia with macrogyria was evident. In conclusion, rarely observed meningoencephalocele case was firstly identified as anatomopathologically in a calf in Diyarbakır province.